abstract：:Solitary fibrous tumors (SFTs) often involve the pleura and also may encompass the peritoneum and nonserosal sites. On occasion SFTs mimics other neoplasms, including desmoplastic mesothelioma. CD-34, initially characterized as a hematopoietic progenitor cell antigen, recently has been identified in a small number of ...

journal_title：Human pathology

authors： Flint A,Weiss SW

更新日期：1995-04-01 00:00:00

abstract：:Human immunodeficiency virus-associated nephropathy (HI-VAN) is a common form of nephropathy present in HIV-infected individuals that clinically presents with proteinuria that is frequently in the nephrotic range, less often with hematuria, and with a course that may evolve to irreversible azotemia ultimately resultin...

journal_title：Human pathology

authors： Rey L,Viciana A,Ruiz P

更新日期：1995-04-01 00:00:00

abstract：:In the present study the clinical and pathological evolution of a reactive-like B-cell lymphoproliferative disorder with an unusually high content of T cells is described. Immunogenotypic analysis showed that the same phenotypically atypical B-cell clone, characterized by the unusual presence of an immunoglobulin (Ig)...

journal_title：Human pathology

authors： Dolcetti R,De Re V,Carbone A,De Vita S,Gloghini A,Tirelli U,Pasquotti B,Boiocchi M

更新日期：1995-03-01 00:00:00

abstract：:We describe a method for the immunocytochemical assessment of estrogen receptor (ER) status on routinely processed, formalin-fixed tissue using a recently developed commercially available monoclonal antibody (Dako 1D5) with a microwave antigen retrieval technique. A series of 90 cases of human breast carcinoma was ana...

journal_title：Human pathology

authors： Goulding H,Pinder S,Cannon P,Pearson D,Nicholson R,Snead D,Bell J,Elston CW,Robertson JF,Blamey RW

更新日期：1995-03-01 00:00:00

abstract：:It has been suggested that inferences about fetal karyotype can be made from examination of placental and decidual histology in early, spontaneous abortions (SABs). We assessed the reproducibility and predictive value of histologic features in 75 karyotyped, first trimester SABs; 32% (24 of 75) had normal male karyoty...

journal_title：Human pathology

authors： Genest DR,Roberts D,Boyd T,Bieber FR

更新日期：1995-02-01 00:00:00

abstract：:Thrombosis of large fetal vessels in the placenta leads to regions of downstream avascular villi (AV). Avascular villi have been associated with adverse outcomes in anecdotal reports, but no controlled study of their significance has been done. We prospectively gathered cases of extensive AV (n = 29) occurring over a ...

journal_title：Human pathology

authors： Redline RW,Pappin A

更新日期：1995-01-01 00:00:00

abstract：:We describe a patient with adenosquamous carcinoma of the prostate. His history suggests a common histogenesis of the glandular and squamous elements of the tumor. A 60-year-old white man had adenocarcinoma of the prostate diagnosed by biopsy and then underwent radical prostatectomy, which showed adenosquamous carcino...

journal_title：Human pathology

authors： Gattuso P,Carson HJ,Candel A,Castelli MJ

更新日期：1995-01-01 00:00:00

abstract：:Tumor proliferation in bladder cancer is associated with tumor behavior. To assess the association between Ki-67 labeling index (LI), p53, and c-erbB-2 overexpression, formalin-fixed tissue samples of 160 patients with transitional cell carcinoma (TCC) of the urinary bladder were studied by immunohistochemistry. Ki-67...

journal_title：Human pathology

authors： Moch H,Sauter G,Mihatsch MJ,Gudat F,Epper R,Waldman FM

更新日期：1994-12-01 00:00:00

abstract：:Recent polymerase chain reaction (PCR)-based studies focused on the detection of immunoglobulin heavy chain gene (IgH) rearrangements have suggested that clonal populations may be amplified more easily from certain categories of B-cell neoplasia than others and that primer makeup can be a critical factor in successful...

journal_title：Human pathology

authors： Segal GH,Jorgensen T,Masih AS,Braylan RC

更新日期：1994-12-01 00:00:00

abstract：:Lymphoepithelial cysts with histological features characteristic of branchial cleft cysts have been reported to occur rarely in the thyroid gland. To our knowledge only six cases of this lesion have been reported. Since these reports brought this entity to our attention, we have noted that intrathyroidal lymphoepithel...

journal_title：Human pathology

authors： Apel RL,Asa SL,Chalvardjian A,LiVolsi VA

更新日期：1994-11-01 00:00:00

abstract：:The control of colorectal cancer is currently dependent on early detection, and its prevention requires the recognition and treatment of its precursor lesions. The adenoma has been established as the precursor of colorectal carcinoma in the general population. Among patients with inflammatory bowel disease (IBD), dysp...

journal_title：Human pathology

authors： Pascal RR

更新日期：1994-11-01 00:00:00

abstract：:The evolution of sequential histological changes from normal cells through invasive cancer affords the cancer biologist the opportunity to identify separate molecular steps involved in cancer progression. As one studies the development of human carcinoma, it becomes apparent that multiple genetic alterations affecting...

journal_title：Human pathology

authors： Stemmermann G,Heffelfinger SC,Noffsinger A,Hui YZ,Miller MA,Fenoglio-Preiser CM

更新日期：1994-10-01 00:00:00

abstract：:We examined the infection of herpes simplex virus (HSV), human cytomegalovirus (HCMV), and Epstein-Barr virus (EBV) in 61 autopsy cases with secondary diffuse interstitial pneumonia (SDIP) by immunohistochemistry and compared our findings with those in 46 individuals without lung complications. There was no significan...

journal_title：Human pathology

authors： Oda Y,Okada Y,Katsuda S,Nakanishi I

更新日期：1994-10-01 00:00:00

abstract：:Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 microns...

journal_title：Human pathology

authors： Orsatti G,Greenberg PD,Rolfes DB,Ishak KG,Paronetto F

更新日期：1994-09-01 00:00:00

abstract：:High cathepsin D (cath-D) concentration in breast cancer cytosol is associated with increased risk of metastasis. To specify the relative contribution of the different cells types responsible for cath-D level in cytosol, we validated semiquantitative cath-D immunoperoxidase staining on formalin-fixed, paraffin-embedde...

journal_title：Human pathology

authors： Roger P,Montcourrier P,Maudelonde T,Brouillet JP,Pages A,Laffargue F,Rochefort H

更新日期：1994-09-01 00:00:00

abstract：:Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjace...

journal_title：Human pathology

authors： Aihara M,Truong LD,Dunn JK,Wheeler TM,Scardino PT,Thompson TC

更新日期：1994-08-01 00:00:00

abstract：:Two patients, 14 and 46 years of age, presented with diffuse, rapidly growing intracerebral tumors leading to death 6 1/2 and 9 1/2 months, respectively, after diagnosis. Histological examination showed sheets of moderate-sized tumor cells with clear cytoplasm and central nuclei interrupted by delicate arciform vascul...

journal_title：Human pathology

authors： Mrak RE

更新日期：1994-08-01 00:00:00

abstract：:Studies on melanoma cell lines indicate the expression of actin-binding protein (ABP), a peripheral cytoplasmic protein that crosslinks actin, is important for melanoma cell motility. We used an ABP-specific monoclonal antibody to characterize ABP expression in 18 benign nevi and 28 primary and metastatic malignant me...

journal_title：Human pathology

authors： Bouffard D,Duncan LM,Howard CA,Mihm MC Jr,Byers HR

更新日期：1994-07-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is associated in 95% of cases with the Philadelphia chromosome (Ph1) by cytogenetic analysis. This acquired karyotypic abnormality is the product of a balanced translocation between the c-abl oncogene on chromosome 9 and the breakpoint cluster region (BCR) gene on chromosome 22. The ...

journal_title：Human pathology

authors： McClure JS,Litz CE

更新日期：1994-06-01 00:00:00

abstract：:A case of scrotal and penile extramammary Paget's disease (EMPD) and concurrent prostate adenocarcinoma in a 59-year-old patient is presented. Immunohistochemically, the tumor cells of both the EMPD and prostate stained positively for prostate-specific antigen. Six previously reported cases of EMPD associated with pro...

journal_title：Human pathology

authors： Sleater JP,Ford MJ,Beers BB

更新日期：1994-06-01 00:00:00

abstract：:Altered expression of oncogenes and tumor suppressor genes, the normal function of which is to regulate cell growth and differentiation, represents a central event in the pathogenesis of human cancer. Aberrant expression of these genes is often a result of a mutational event. In vitro amplification of DNA with the pol...

journal_title：Human pathology

authors： Loda M

更新日期：1994-06-01 00:00:00

abstract：:This study assessed squamous cell papillomas of the human esophagus for the presence of human papillomavirus (HPV) and correlated the results with histological features. Twenty-three lesions obtained by endoscopic biopsy from 17 patients were studied, first by in situ hybridization (ISH) for HPV types 6-11, 16-18, 18,...

journal_title：Human pathology

authors： Carr NJ,Bratthauer GL,Lichy JH,Taubenberger JK,Monihan JM,Sobin LH

更新日期：1994-05-01 00:00:00

abstract：:Our previous investigations of transforming growth factor types beta 1 and beta 2 (TGF beta s) showed negative or positive autocrine growth regulation of gliomas in vitro. Near-diploid gliomas were inhibited by the TGF beta s, whereas a stimulatory response correlated with progressive anaplasia and karyotypic divergen...

journal_title：Human pathology

authors： Jennings MT,Kaariainen IT,Gold L,Maciunas RJ,Commers PA

更新日期：1994-05-01 00:00:00

abstract：:Pseudovascular adenoid squamous cell carcinoma (PASCC) is a variant epithelial neoplasm with the ability to simulate the growth pattern of angiosarcoma. It has been documented in the breast, skin, and, recently, lung. We describe three additional examples of pulmonary PASCC occurring in two men and one woman. The pati...

journal_title：Human pathology

authors： Nappi O,Swanson PE,Wick MR

更新日期：1994-04-01 00:00:00

abstract：:Xanthoma is a localized collection of cholesterol-laden histiocytes that is usually idiopathic, but may be seen in patients with hyperlipidemia. We report seven cases of xanthoma involving the prostate, including one arising in a patient with mild hyperlipidemia. Prostatic xanthoma appeared as a solitary microscopic l...

journal_title：Human pathology

authors： Sebo TJ,Bostwick DG,Farrow GM,Eble JN

更新日期：1994-04-01 00:00:00

abstract：:We studied the histopathology and clinicopathologic correlates of invasive cavitary pulmonary aspergillosis in 11 immunosuppressed patients with disseminated malignancy. In most patients cavities were produced by separation of necrotic from viable lung, resulting in an intracavitary sequestrum ("lung ball"). Central d...

journal_title：Human pathology

authors： Pai U,Blinkhorn RJ Jr,Tomashefski JF Jr

更新日期：1994-03-01 00:00:00

abstract：:Although the histopathologic patterns associated with Helicobacter pylori infection have been described, details of the interaction between bacteria, epithelial cells, and inflammatory cells remain elusive. One of the limiting factors has been the lack of a staining technique that allows the simultaneous visualization...

journal_title：Human pathology

authors： Genta RM,Robason GO,Graham DY

更新日期：1994-03-01 00:00:00

abstract：:We report four unusual cases of hyalinizing trabecular thyroid tumors, three of which displayed capsular and/or blood vessel invasion and were classified as minimally invasive carcinomas. These three patients were all euthyroid women aged 18, 39, and 62 years. The youngest patient also had familial polyposis, while th...

journal_title：Human pathology

authors： Molberg K,Albores-Saavedra J

更新日期：1994-02-01 00:00:00

abstract：:Most histopathologic descriptions of influenza pneumonia are based on autopsy findings in fatal cases during epidemics and pandemics of influenza. We describe the histologic findings of influenza pneumonia observed in biopsy material derived from six sporadic cases of influenza (influenza A, four cases; influenza B, o...

journal_title：Human pathology

authors： Yeldandi AV,Colby TV

更新日期：1994-01-01 00:00:00

abstract：:Among 236 aortic valves surgically excised at the Mayo Clinic in 1990 (mean patient age, 66 years; age range, 10 to 92 years), 154 (65%) were stenotic, 58 (25%) were insufficient, and 24 (10%) were both stenotic and insufficient. Pure stenosis was related to calcification, and causes included degenerative (51%), bicus...

journal_title：Human pathology

authors： Dare AJ,Veinot JP,Edwards WD,Tazelaar HD,Schaff HV

更新日期：1993-12-01 00:00:00

abstract：:Histopathologic lesions in the central nervous system (CNS) of 400 autopsy cases of the acquired immunodeficiency syndrome (AIDS) collected from 1982 to 1990 were studied. Lesions most closely associated with human immunodeficiency virus (HIV) infection in the CNS (perivascular macrophages, nodular encephalomyelitis, ...

journal_title：Human pathology

authors： Rhodes RH

更新日期：1993-11-01 00:00:00

abstract：:Ciliated metaplasia (CM) of gastric mucosa is common in Japanese individuals but rare in whites. We studied 36 consecutive gastrectomies from Chinese individuals for the presence of CM. The gastrectomies were performed for adenocarcinoma (n = 22), benign ulcer (n = 13), and malignant lymphoma (n = 1). Ciliated metapla...

journal_title：Human pathology

authors： Chan WY,Hui PK,Leung KM,Robertson CS,Chung SC

更新日期：1993-10-01 00:00:00

abstract：:Monocytoid B-cell lymphoma (MBCL) is a newly recognized, morphologically and immunologically distinct, low-grade B-cell neoplasm that may exist as a pure morphologic entity or as a component of a composite lymphoma. To determine whether cytogenetic abnormalities exist in cases of MBCL, fresh tissue from four lymphoma ...

journal_title：Human pathology

authors： Slovak ML,Weiss LM,Nathwani BN,Bernstein L,Levine AM

更新日期：1993-10-01 00:00:00

abstract：:We report a case of a newborn female with a rare tumor, a congenital sarcoma, presenting as an abdominal mass. Laparotomy demonstrated the tumor arising from the wall of the terminal ileum. Histologically, the tumor tissue was indistinguishable from clear cell sarcoma of the kidney and was composed of proliferating ce...

journal_title：Human pathology

authors： Kataoka Y,Shimada H,Sugimoto T,Mine H,Hachitanda Y,Doi Y,Sawada T,Weeks DA

更新日期：1993-09-01 00:00:00

abstract：:We investigated the use of remote video microscopy (telepathology) to assist in the diagnosis of 52 neurosurgical frozen section cases. The TelMed system (Discovery Medical Systems, Overland Park, KS), in which the referring pathologist selects appropriate fields for transmission to the consultant, was used for the st...

journal_title：Human pathology

authors： Becker RL Jr,Specht CS,Jones R,Rueda-Pedraza ME,O'Leary TJ

更新日期：1993-08-01 00:00:00

abstract：:To establish whether an intramural left anterior descending coronary artery (LADA) is a simple anatomic or a singularly pathologic variant we studied 39 hearts, each with an intramural course of the LADA and no coronary artery disease, valvular derangement, cardiomyopathy, or congenital anomaly. Seventeen of the 39 he...

journal_title：Human pathology

authors： Morales AR,Romanelli R,Tate LG,Boucek RJ,de Marchena E

更新日期：1993-07-01 00:00:00

abstract：:Proliferative lesions of breast duct epithelium are associated with an increased risk of subsequent carcinoma. Fine-needle aspiration criteria for these lesions are poorly defined; most studies are retrospective and do not clearly use the classification of Page and Rogers. Suggested criteria for "atypia" include crowd...

journal_title：Human pathology

authors： Stanley MW,Henry-Stanley MJ,Zera R

更新日期：1993-06-01 00:00:00

abstract：:Atypical fibro-osseous lesions, usually in the proximal femur, are a common consultative diagnostic problem. This is due to the fact that they contain a variety of patterns individually reminiscent of fibrous dysplasia, fibroxanthoma (non-ossifying fibroma), myxofibroma, lipoma, cyst, bone infarct, Paget's disease, an...

journal_title：Human pathology

authors： Ragsdale BD

更新日期：1993-05-01 00:00:00

abstract：:To obtain a better understanding of steroid metabolism associated with adrenocortical malignancy we studied steroidogenesis in nine cases of adrenocortical carcinoma (six with Cushing's syndrome, two without clinically significant adrenocortical hormonal abnormalities, and one with primary aldosteronism) by analyzing ...

journal_title：Human pathology

authors： Sasano H,Suzuki T,Nagura H,Nishikawa T

更新日期：1993-04-01 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) and c-myc p62 oncoprotein are two nuclear proteins expressed in proliferating and transformed cells. They can be recognized immunohistochemically in paraffin sections by the monoclonal antibodies PC-10 and c-myc 1-9E10, respectively. On the other hand, nucleolar organizer regi...

journal_title：Human pathology

authors： Korkolopoulou P,Patsouris E,Pangalis G,Tsenga A,Elemenoglou J,Thomas-Tsangli E,Spandidos D,Kittas C

更新日期：1993-04-01 00:00:00